Mayim Bialik as Amy Fowler
Oh look, it’s Sheldon’s highly intelligent girlfriend Amy Fowler. In real life, Mayim Bialik is also wicked smart as she holds a B.S. degree in neuroscience, along with minors in Hebrew and Jewish studies. Moreover she has a Ph.D in neuroscience. Told you she was crazy smart on and off screen.
Bialik has been nominated four times for the Primetime Emmy Award as well. The 41 year old actress classifies herself as a feminist.
Simon Helberg as Howard Wolowitz
Simon Helberg plays Howard Wolowitz, an engineer and astronaut with an overbearing mother. Eventually the nerdy engineer marries Bernadette, showing serious character development for Wolowitz.
The 36 year old was nominated for a Golden Globe for his role in the 2016 film Florence Foster Jenkins. Helberg is also a musician and comedian.