Grey’s Anatomy
UGH. Why, Shonda Rhimes? Why?! 12 scenes later and fans have yet to forgive you for killing off the wonderful Denny Duquette. Who mere hours before survived a heart transplant and proposed to the lovely Dr. Izzie Stevens. Watching Izzie clutch at her fiance’s dead body, crying her poor heart out, is enough to make you seriously want to pull your hair out.
Boy Meets World
At the very end, when Mr. Feeny admits his complete adoration for the whole gang and dismisses his class for the last time. Let the water works begin.