Bo Jackson – Oakland Raiders
Bo Jackson is a pure legend. He’s only one of a few athletes that was named All-Star in two major sports, baseball and football. To this day, he is still regarded as one of the greatest athletes of all time, and there’s no denying that. It all however came to a short and brutal end when he suffered an NFL injury in 1991 to his left left. Jackson was diagnosed with avascular necrosis of the hip joint and lost all of the cartilage supporting his hip, forcing him into early retirement.
Brandon Roy – Minnesota Timberwolves
For five seasons, Brandon Roy was an unstoppable force on the court, but he was sadly ushered into retirement due to a degenerative knee condition. During his professional career, Roy was NBA Rookie of the Year Award in a near unanimous vote, impressive. He was also selected as a reserve in the 2008, 2009, and 2010 All-Star games. He played the most minutes of any Western Conference player, and even tied for most points in the West in the 2008 season, and played the most minutes of any player during the 2009 season. While he would make a comeback in 2012, he played for just five games, and had to re-retire.