Ki Jana Carter – Cincinnati Bengals
Carter’s career at Penn State earned him All-American honors, and he was the No. 1 draft pick in 1995 by the Cincinnati Bengals. While most consider his NFL career a bust from the get-go, there’s no denying he was talented. He tore a ligament in his knee during his first preseason game of his rookie year, and just never fully recovered. Carter would miss the entire 1995 season and was plagued with countless injuries after. He retired in 1999.
LeCharles Bentley – Cleveland Browns
Bentley’s career with his dream team, the Cleveland Browns, came to a screeching halt in 2006 during the first 11-on-11 drills in camp for Cleveland. He suffered from a staph infection and needed four additional surgeries following his knee injury. Bentley claimed that the infection was so horrible that he almost had his leg amputated. He later sued the Browns over the infection but the matter was settled out of court in 2012.